AHF South Africa has been operational since 2002, when it opened its first global clinic, the Ithembalabantu People’s Hope Clinic, in Umlazi.  

Since then, operations have expanded to 61 facilities across four provinces. In collaboration with the Department of Health and local governments in KwaZulu-Natal, Eastern Cape, and Gauteng, AHF South Africa supports the delivery of high-quality, comprehensive services for HIV, sexually transmitted infections (STIs), and tuberculosis (TB) under the HIV, AIDS, STIs, and TB (HAST) framework.  

AHF supports the South African government's efforts to establish effective models for delivering HAST services, uphold standards of care, and guide the strategic implementation of these services. Currently, AHF provides support to 61 facilities through direct service delivery, training and capacity building, mentoring, monitoring and evaluation, and by supplying essential resources like equipment and infrastructure.  

Recognizing the importance of social determinants of health—such as access to housing, healthcare, and nutrition—AHF South Africa expanded its services in 2021 by launching the Food for Health program to ensure holistic care for improved health outcomes.